METABOLOMICS FACILITY - PUBLICATIONS LIST

  1. Wilkinson, M.D., Tosi, P., Lovegrove, A., Corol, D.I., Ward, J.L., Palmer, R., Powers, S., Passmore, D., Webster, G., Marcus, S.E., Knox, J.P., Shewry P.R. (2017) The Gsp-1 genes encode the wheat arabinogalactan peptide. J. Cereal Sci., 74, 155-164.
  2. Shwery, P.R., Corol, D.I., Jones, H.D., Beale, M.H., Ward, J.L. (2017) Defining diversity in wheat grain by 1H-NMR spectroscopy of polar metabolites. Mol. Nut. Food Res. In press.
  3. Coutinho, I.D., Baker, J.M., Ward, J.L., Beale, M.H., Creste, S., Cavalheiro, A.J. (2016). Metabolite profiling of sugarcane genotypes and identification of flavonoid glycosides and phenolic acids. J. Ag. Food Chem., 64, 4198-4206.
  4. Greenslade, A.F.C., Ward, J.L., Martin, J., Corol, D.I., Clark, S.J., Smart, L.E., Aradottir, G.I. (2016). Triticum monococcum lines with distinct metabolic phenotypes and phloem based resistance to the bird cherry oat aphid Rhopalosiphum padi. Ann. Applied Biology, 168, 435-449.
  5. Garg, R., Brennan, L., Price, R.K., Wallace, J.M.W., Strain, J.J., Gibney, M.J., Shewry, P.R., Ward, J.L., Garg, L., Welch, R.W. (2016). Using NMR-Based Metabolomics to Evaluate Postprandial Urinary Responses Following Consumption of Minimally Processed Wheat Bran or Wheat Aleurone by Men and Women. Nutrients, 8:96; doi:10.3390/nu8020096.
  6. Mumm, R., Hageman, J.A., Calingacion, M.N., deVos, R.C.H., Jonker, H.H., Erban, A., Kopka, J., Hanson, T.H., Laursen, K.H., Schjoerring, J.K., Ward, J.L., Beale, M.H., et. al. (2016) Multi-platform metabolomics analyses of a broad collection of fragrant and non-fragrant rice varieties reveals the high complexity of grain quality characteristics Metabolomics, 12, 1-38.
  7. Wu, Y., Dobermann, D., Beale, M.H., Ward, J.L. (2016). Acutifoliside, a novel benzoic acid glycoside from Salix acutifolia. Nat. Prod. Research, 30, 1731-1739.
  8. Corol, D.I., Ravel, C. Rakszegi, M., Charmet, G., Bedo, Z., Beale, M.H., Shewry, P.R., Ward, J.L. (2016) 1H-NMR screening for the high-throughput determination of genotype and environmental effects on the content of asparagine in wheat grain. Plant Biotechnology Journal, 14, 128-39
  9. Gonzalez-Thuillier, I., Salt, L., Chope, G., Penson, S., Skeggs, P., Tosi, P., Powers, S.J., Ward, J.L., Wilde, P., Shewry, P.R., Haslam, R.P. (2015) Distribution of Lipids in the Grain of Wheat (cv. Hereward) Determined by Lipidomic Analysis of Milling and Pearling Fractions. J. Ag. Food Chem. 63, 10705-10716.
  10. Ward, J., Rakszegi, M., Bedo, Z., Shewry, P.R., Mackay, I. (2015) Differentially penalized regression to predict agronomic traits from metabolites and markers in wheat. BMC Genetics, 16 (19), Feb 2015. DOI: 10.1186/s12863-015-0169-0
  11. Keaveney, E.M., Price, R.K., Hamill, L.L., Wallace, J.M.W., McNulty, H., Ward, M., Strain, J.J., Ueland, P.M., Molloy, A.M., Piironen, V., von Reding, W., Shewry, P.R., Ward, J.L., Welch, R.W. (2015) Postprandial plasma betaine and other methyl donor-related responses after consumption of minimally-processed wheat bran or wheat aleurone, or wheat aleurone incorporated into bread, British Journal of Nutrition, 113 (3), 445-53
  12. Corol, D.I., Harflett, C., Beale, M.H., Ward, J.L. (2014) An efficient high throughput metabotyping platform for screening biomass willows. Metabolites, 4(4), 946-976.
  13. Scott, I., Ward, J., Miller, S., Beale, M. (2014) Opposite variations in fumarate and malate dominate metabolic phenotypes of Arabidopsis salicylate mutants with abnormal biomass under chilling. Physiologia Plantarum, 152(4), 660-674
  14. Costabile, A., Santarelli, S., Claus, S.P., Sanderson, J., Hudspith, B.N., Brostoff, J., Ward, J.L., Lovegrove, A., Shewry, P.R., Jones, H.E., whitley, A.M., Gibson, G.R. (2014). Effect of Breadmaking Process on In Vitro Gut Microbiota Parameters in Irritable Bowel Syndrome. Plos One, http://dx.doi.org/10.1371/journal.pone.0111225
  15. Perez-Fons, L., Wells, T., Corol, D-I., Ward, J.L., Gerrish, C., Beale, M.H., Seymour, G.B., Bramley, P.M. and Fraser, P.D. (2014) A genome-wide metabolomic resource for tomato fruit from Solanum pennellii Nature:Scientific Reports, 4 : 3859 | DOI: 10.1038/srep03859
  16. Scott, I.M., Lin, W., Liakata, M., Wood, J.E., Vermeer, C.P., Allaway, D., Ward, J.L., Draper, J., Beale, M.H., Corol, D.I., Baker, J.M., King, R.D. (2013). Merits of random forests emerge in evaluation of chemometric classifiers by external validation. Analytica Chimica Acta, 801, 22-33.
  17. Shewry, P., Hawkesford, M., Piironen, V., Lampi, A-M., Gebruers, K., Boros, D., Andersson, A., Åman, P., Rakszegi, M., Bedo, Z., Ward, J. (2013) Natural Variation in Grain Composition of Wheat and Related Cereals. J. Agric. Food Chem.61, 8295-8303
  18. Beste, D.J.V., Noh, K., Niedenfuhr, S., Mendum, T.A., Hawkins, N.D., Ward, J.L., Beale, M.H., Wiechart, W., McFadden, J. (2013) Carbon fixation and a mixed diet for the intra cellular tuberculosis bacillus.13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis. Cell:Chemistry and Biology, 20, 1012-1021.
  19. Studholme, D.J., Harris, B., Le Cocq, K., Winsbury, R., Perera, V., Ryder, L., Beale, M.H., Ward, J.L., Thornton,C.R., Grant, M. (2013). Investigating the beneficial traits of Trichoderma hamatum GD12 for sustainable agriculture-insights from genomics. Frontiers in Plant Science, 4, 258-. doi: 10.3389/fpls.2013.00258.
  20. Hodge, S., Ward, J.L., Beale, M.H., Bennett, M., Mansfield, J.W., Powell, G. (2013). Aphid-Induced Accumulation of Trehalose in Arabidopsis thaliana is Insect Density-Dependent and Systemic. Planta 237, 1057-1064.
  21. Andersson, A.A.M., Andersson, R., Piironen V., Lampi, A-M., Nystrom, L., Boros, D., Fras, A., Gebruers, K., Courtin, C.M., Delcour, J.A., Rakszegi, M., Bedo, Z., Ward, J.L., Shewry, P.R., Aman, P. (2013). Contents of dietary fibre components and their relation to associated bioactive components in whole grain wheat samples from the HEALTHGRAIN diversity screen. Food Chem., 136, 1243-1248.
  22. Bernillon, S., Biais, B., Deborde, C., Maucourt, M., Cabasson, C., Gibon, Y., Hansen, T.H., Husted, S., de Vos, R.C.H., Mumm, R., Jonker, H., Ward, J.L., Miller, S.J., Baker, J.M., Burger, J., Tadmor, Y., Beale, M.H., Schjoerring, J.K., Schaffer, A.A., Rolin, D., Hall, R.D., Moing, A. (2013) Metabolomic and elemental profiling of melon fruit quality as affected by genotype and environment. Metabolomics 9, 57-77.
  23. Shewry, P.R., Mitchell, R.A.C., Tosi, Wan Y., Underwood, C., Lovegrove, A., Freeman, J., Toole, G.A., Mills, E.N.C., Ward, J.L. (2012). An integrated study of grain development of wheat (cv. Hereward). J. Cereal Sci. 56, 21-30.
  24. Shewry, P.R., Charmet, G., Branlard, G., Lafiandra, D., Gergely, S., Salgo, A., Saulnier, L., Bedo, Z., Mills, E.N.C., Ward, J.L. (2012) Developing new types of wheat with enhanced health benefits Trends in Food Science and Technology, 25, Special Issue: SI, 70-77.
  25. Corol, D-I., Ravel, C., Raksegi, M., Bedo, Z., Charmet, G., Beale, M.H., Shewry, P.R., Ward, J.L. (2012). Effects of Genotype and Environment on the Contents of Betaine, Choline, and Trigonelline in Cereal Grains. J. Agric. Food Chem., 60, 5471-5481
  26. Beale, M.H. and Ward, J.L. (2012) Realising the potential of plant metabolomics. Pharmaceutical Biology 50(5), 611-673.
  27. Ward, J.L., Baker, J.M., Llewellyn, A.M., Hawkins, N.D., Beale, M.H. (2012) Unexpected hemiterpenoids in Arabidopsis, revealed by metabolite fingerprinting, give new insights into C/N metabolic balancing. Pharmaceutical Biology 50(5), 611-673.
  28. Andralojc, P.J., Madgwick, P.J., Keys, A.J., Ward, J.L., Beale, M.H., Loveland, J.E., Jackson, P.J., Willis, A.C., Gutteridge, S and Parry, M.A.J. (2012) CA1P phosphatase - evidence for a wider role in plant Rubisco regulation. The Biochemical Journal 442, 733-742
  29. Sun, F., Suen, P.K., Zhang, Y., Liang, C., Carrie, C., Whelan, J., Ward, J.L., Hawkins, N.D., Jiang, L., Lim, B.L. (2012) A dual-targeted purple acid phosphatase in Arabidopsis thaliana moderates carbon metabolism and its overexpression leads to faster plant growth and higher seed yield. New Phytologist 194(1), 206-219.
  30. Shewry, P.R., Ward, J.L. (2012) Exploiting genetic variation to improve wheat composition for the prevention of chronic diseases. Food and Energy Security 1(1): 47-60
  31. Rosén, L.A.H., Östman, E.M., Shewry, P.R., Ward, J.L., Andersson, A.A.M/. Piironen, V., Lampi, A., Rakszegi, M., Bedö, Z., Björck, I.M.E. (2011) Postprandial glycaemia, insulinaemia and satiety responses in healthy subjects after wholegrain rye bread made from different rye varieties. J. Ag. Food Chem. 59, 12139-12148
  32. Quraishi, U.M.; Murat, F., Abrouk, M., Pont, C., Confolent, C., Oury, F.X., Ward, J., Boros, D., Gebruers, K., Delcour, J.A., Courtin, C.M., Bedo, Z., Saulnier, L., Guillon, F., Balzergue, S., Shewry, P.R., Feuillet, C., Charmet, G., Salse, J. (2011) Combined meta-genomics analyses unravel candidate genes for the grain dietary fiber content in bread wheat (Triticumaestivum L.) Functional and Integrative Genomics 11(1), 71-83.
  33. Ward, J.L., Baker, J.M., Llewellyn, A.M., Hawkins, N.D., Beale, M.H. (2011) Metabolomic analysis of Arabidopsis reveals hemiterpenoid glycosides as products of a nitrate ion-regulated, carbon flux overflow. Proc. Nat. Acad. Sci. USA 108(26), 10762-10767.
  34. Beste, D.J.V., Bonde, B., Hawkins, N., Ward, J.L., Beale, M.H., Noack, S., Noeh, K., Kruger, N.J., Ratcliffe, R.G., McFadden, J. (2011) (13)C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires IsocitrateLyase and Carbon Dioxide Fixation. Plos Pathogens 7(7), article no: e1002091
  35. Hodge, S., Ward, J.L., Galster, A.M., Beale, M.H., Powell, G. (2011) The effects of a plant defence priming compound, beta-aminobutyric acid, on multitrophic interactions with an insect herbivore and a hymenopterous parasitoid. Biocontrol, 56, 699-711.
  36. Shewry, P.R., van Schaik, F., Ravel, C., Charmet, G., Rakszegi, M., Bedõ, Z., Ward, J. (2011) Genotype and Environment Effects on the Contents of Vitamins B1, B2, B3 and B6 in Wheat Grain. J. Ag. Food Chem.59, 10564-10571
  37. Shewry, P.R., Ward, J.L., Zhao, F., Ravel, C., Charmet, G., Lafiandra, D., Bedo, Z. (2011) Improving the Health Benefits of Wheat. Czech J. Genet. Plant Breed.,47, 2011 (Special Issue): S169-S173
  38. Ward, J.L. and Shewry, P.R. (2010). Future Prospects for the Analysis of Bioactive Components in Cereal Grain.Cereal Foods World. 55(2), 71-75
  39. Ward, J.L., Baker, J.M., Miller, S.J., Deborde, C., Maucourt, M., Biais, B., Rolin, D., Moing, A., Moco,S., Vervoort, J., Lommen, A., Schäfer, H., Humpfer, E., Beale, M.H. (2010) An inter-laboratory comparison demonstrates that [1H]-NMR metabolite fingerprinting is a robust technique for collaborative plant metabolomic data collection Metabolomics, 6, 263-273
  40. Shewry, PR, Piironen, V, Lampi, A-M, Edelman, M, Kariluoto, S, Nurmi, T, Nystr_m, L, Ravel, C, Charmet, C, Andersson, A, Åman P, Boros, D, Gebruers, K, Dornez, E, Courtin, C, Delcour, C, Rakszegi, M, Bedo, Z and Ward, J. (2010). The HEALTHGRAIN wheat diversity screen: effects of genotype and environment on phytochemicals and dietary fiber components. J. Ag. Food Chem,
  41. Shewry, P.R., Piironen, V., Lampi, A., Edelmann, M., Kariluoto, S., Nurmi, T., Andersson, A.A.M., Åman, P., Fra_, A., Boros, D., Gebruers, K., Dornez, E., Courtin, C.M., Delcour, J.A., Ravel, C., Charmet, G., Rakszegi, M., Bedo, Z., Ward, J.L. (2010) Effects of genotype and environment on the content and composition of phytochemicals and dietary fiber components in rye in the HEALTHGRAIN diversity screen. J. Ag. Food Chem, 58(17), 9372-9383.
  42. Fernandez-Orozco, R, Li, L, Harflett, C, Shewry, RP and Ward, J.L. (2010) Effects of environment and genotype on phenolic acids in wheat in the HEALTHGRAIN diversity screen. J. Ag. Food Chem, 58(17), 9341-9352.
  43. Ward, J.L., Forcat, S., Beckmann, M., Bennett, M., Miller, S.J., Baker, J.M., Hawkins, N.D., Vermeer,C., Lu, C., Lin, W., Truman, W.M., Beale, M.H., Draper, J., Mansfield, J.W., Grant, M. (2010) The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato. The Plant Journal, 63(3), 443-457.
  44. Lowe, R.G.T., Allwood, J.W., Galster, A., Urban, M., Daudi, A., Canning, G., Ward, J.L., Beale, M.H., Hammond-Kosack, K.E. (2010) A combined 1H NMR and ESI-MS analysis to understand the basal metabolism of plant pathogenic Fusarium species, Molecular Plant-Microbe Interactions, 23(12), 1605-1618.
  45. Mehrshahi, P., Gonzalez-Jorge, S., Akhtar, T., Ward, J.L., Santoyo-Castelazo, A., Marcus, S., Lara-Núñez, A., Hawkins, N., Beale, M.H., Barrett, D., Knox, P., Gregory, J., Hanson, A., Bennett, M., Della Penna, D., (2010) Functional analysis of folate polyglutamylation and its essential role in plant metabolism and development. The Plant Journal, 64(2), 267-279.
  46. Shewry, P.R., Gebruers, K., Andersson, A.A.M., Aman, P., Piironen, V., Lampi, A.M., Boros, D., Rakszegi, M., Bedo, Z., Ward, J.L. (2010) Relationship between the Contents of Bioactive Components in Grain and the Release Dates of Wheat Lines in the HEALTHGRAIN Diversity Screen. J. Ag. Food Chem, 59(3), 928-933.
  47. Fu, J., Keurentjes, J.J.B., Bouwmeester, H., America, T., Verstappen, F.W.A., Ward, J.L., Beale, M.H., de Vos, R.C.H/, Dijkstra, M., Scheltema, R.A., Johannes, F., Koornneef, M., Vreugdenhil,D., Breitling, R., Jansen, R.C. (2009), System-wide molecular evidence for phenotypic buffering in Arabidopsis. Nature Genetics 41. 166-7
  48. Carmo-Silva, A.E., Keys, A.J., Beale, M.H., Ward, J.L., Baker, J.M., Hawkins, N.D., Arrabaça, M.C., Parry, M.A.J. (2009). Drought stress increases the production of 5-hydroxynorvaline in two C4 grasses. Phytochemistry, 70, 664-671.
  49. Bean, T.P., Cools, H.J., Lucas, J.A., Hawkins, N.D., Ward, J.L., Shaw, M.W., Fraaije, B.A. (2009). Sterol content analysis suggests altered eburicol14a-demethylase (CYP51) activity in isolates of Mycosphaerellagraminicola adapted to azole fungicides. FEMS Microbiol. Lett., 296, 266-273.
  50. Shewry, P.R., Zhao, F., Gowa, G.B., Hawkins, N.D., Ward, J.L., Beale, M.H., Halford, N.G., Parry, M.A., Abecassis, J. Sulphur Nutrition Differentially Affects the Distribution of Asparagine in Wheat Grain. 2009. Journal of Cereal Science 50, 407-409
  51. Ghannoum, O., Paul, M.M., Ward, J., Beale, M.H., Corol, D.-I., Conroy, J.P. (2008) The sensitivity of photosynthesis to phosphorus deficiency differs between C3 and C4 tropical grasses Functional Plant Biology, Vol 35, 213-221
  52. Howarth, J.R., Parmar, S., Jones, J., Shepherd, C.E., Corol, D-I., Galster, A.M., Hawkins, N.D., Miller, S.J., Baker, J.M., Verrier, P.J., Ward, J.L., Beale, M.H., Barraclough, P.B., Hawkesford, M.J.. (2008) Co-ordinated expression of amino acid metabolism pathway genes in response to N and S-deficiency during wheat grain-filling. J. Exp. Bot, 59(13), 3675-3689.
  53. Shewry, P.R.; Li, L.; Piironen, V.; Lampi, A.M.; Nyström, L.; Rakszegi, M.; Fras, A.; Boros, D.; Gebruers, K.; Courtin, C.M.; Delcour, J.A.; Andersson, A.A.M.; Dimberg, L.; Bed_, Z.; Ward, J.L (2008) Phytochemical and fiber components in oat varieties in the HEALTHGRAIN diversity screen. J. Ag. Food Chem 56 (21), 9777-9784.
  54. Andersson, A.A.M.; Åman, P.; Piironen, V.; Nurmi, T.; Kariluoto, S.; Lampi, A.-M.; Delcour, J.A.; Courtin, C.M.; Gebruers, K.; Li, L.; Ward, J.L.; Shewry, P.R..(2008) Phytochemical and dietary fiber composition of barley varieties in the HEALTHGRAIN diversity screen. J. Ag. Food Chem 56 (21), 9767-9776.
  55. Nyström, L.; Lampi, A.-M.; Andersson, A.; Kamal-Eldin, A.; Gebruers, K.; Courtin, C.M.; Delcour, J.A.; Li, L.; Ward, J.L.;.; Fras, A.; Boros, D.; Rakszegi, M.; Bedo, Z.; Shewry, P.R and Piironen, V. (2008) Phytochemicals and dietary fiber components in rye varieties in the HEALTHGRAIN diversity screen. J. Ag. Food Chem 56 (21), 9758-9766.
  56. Li, L.; Shewry, P.R.; Ward, J.L (2008) Phenolic acids in wheat varieties in the HEALTHGRAIN diversity screen..J Ag. Food Chem 56 (21), 9732-9739.
  57. Ward, J.L; Poutanen, K.; Gebruers, K.; Piironen, V.; Lampi, A.-M.; Nyström, L.; Anderson, A. A. M.; Åman, P.; Boros, D.; Rakszegi, M.; Bedo, Z.; Shewry, P. R . (2008) The HEALTHGRAIN cereal diversity screen: concept, results and prospects..J. Ag. Food Chem 56 (21), 9699-9709.
  58. Keon, J., Antoniw, J., Carzangia, R., Deller, S., Ward, J.L., Baker, J.M., Beale, M.H., Hammond-Kosack, K., Rudd, J.J..(2007) Transcriptional adaptation of Mycosphaerellagraminicola to programmed cell death (PCD) of its susceptible wheat host MPMI, 20(2), 178-193.
  59. Ward, J.L., Baker, J.M., Beale, M. (2007). Recent applications of NMR Spectropscopy in Plant metabolomics FEBS Journal, 274, 1126-1131.
  60. Shewry, P.R., Ward, J.L., Beale, M.H., Baker,J., Baudo, M., Napier, J.A. Are GM and conventionally bred cereals really different? Trends in Food Science and Technology.18. (2007) 201-209
  61. Fiehn, O., Sumner, L.W., Rhee, S.Y., Ward, J., Dickerson, J., Lange, B.M., Lane, G., Roessner, U., Last, R., Nikolau, B. (2007). Minimum Reporting standards for plant biology context information in metabolomic studies. Metabolomics, 3: 195-201
  62. Godfrey, D.D., Hawkesford, M.J., Ward, J.L., Powers, S., Millar, S.J., Shewry, P.R.(2007) The impact of nutrition on the metabolome, protein composition and end-use quality of wheat. In Gluten Proteins 2006 (edGL .Lookhart) Am. Assoc. Cereal Chemists
  63. Sumner, L.W., Amberg, A., Barrett, D., Beale, M.H., Beger, R., Daykin, C.A., Fan, T.W.M., Fiehn, O., Goodacre, R., Griffin, J.L., Hankemeier, T., Hardy, N., Harnly, J., Higashi, R., Kopka, J., Lane, A.N., Lindon, J.C., Marriott, P., Nicholls, A.W., Reily, M.D., Thaden, J.J., Viant, M.R.. (2007). Proposed minimum reporting standards for chemical analysis. Metabolomics, 3, 211-221.
  64. Baker, J.M., Hawkins, N.D., Ward, J.L., Lovegrove, A., Napier, J.A., Shewry, P.R., Beale, M.H. (2006). A metabolomic study of substantial equivalence of field-grown GM wheat.Plant Biotechnology Journal, 4(4), 381-392.
  65. Chilley, P., Casson, S., Tarkowski, P., Hawkins, N., Wang, K., Hussey, P., Beale, M., Sandberg, G., Lindsey, K. (2006) The POLARIS peptide of Arabidopsis regulates auxin transport and root growth via effects on ethylene signalling. Plant Cell,18, (11): 3058-3072
  66. Hey, S.J., Powers, S.J., Beale, M.H., Hawkins, N.D., Ward, J.L., Halford, N.D.(2006) Enhanced seed phytosterol accumulation through expression of a modified HMG-CoA reductase. Plant Biotechnology Journal.4, 219-229
  67. Rasha El-Kassas, ZaharaaKaram El-Din, Michael H. Beale, Jane L. Ward and Richard N. Strange. (2005) Bioassay-led identification of Myrotheciumverrucariaand verrucarrinA as germination inhibitors of Orobanchecrenata. Weed Research, 45, 211-219
  68. Gopalakrishnan, S., Beale, M.H., Ward, J.L. and Strange, R.N. (2005) Chickpea wilt: identification and toxicity of 8-O-methyl-fusarubin from Fusariumacutatum, Phytochemistry, 66, 1536-1539
  69. Cornah, J.E., Germain, V., Ward, J.L., Beale, M.H., Smith, S.M. (2004) Lipid Utilisation, gluconeogenesis and seedling growth in Arabidopsis mutants lacking the glyoxylate cycle enzyme malate synthase. J. Biol. Chem., 279, 42916-42923
  70. Naested H, Holm A, Jenkins T, Nielsen HB, Harris CA, Beale MH , Andersen M, Mant A, Scheller H, Camara B, Mattsson O, Mundy J (2004) Arabidopsis VARIEGATED 3 encodes a chloroplast-targeted, zinc-finger protein required for chloroplast and palisade cell development J Cell Science, 117, 4807-4818.
  71. Bino, R.J., Hall, R.D., Feihn, O, Beale, M.H. et al (2004) Potential of Metabolomics as a Functional Genomics Tool. Trends in Plant Science. 9, 418-425
  72. Ward, J. L., Harris, C., Lewis, J. and Beale, M. H. (2003) Assessment of 1H-NMR spectroscopy and multivariate analysis as a technique for metabolite fingerprinting of Arabidopsis thaliana. Phytochemistry, 62, 949-957.
  73. Beale, M.H., Dupree, P., Lilley, K., Beynon, J., Trick, M., Clarke, J., Bevan, M., Bancroft, I., Jones, J., May, S., van de Sande, K. and Leyser, O (2002) GARNet, the Genomic Arabidopsis Resource Network, Trends in Plant Sciences,7, 145-147.
  74. Hall, R, Beale, MH, Fiehn, O., Hardy, N., Sumner, L and Bino, R. (2002) Plant metabolomics: The missing link in functional genomic strategies Plant Cell, 14, 1437-1440.
  75. Williams, J.S., Hall, S. A., Hawkesford, M.J., Beale, M. H. and Cooper, R. M. (2002) Elemental Sulfur and Thiol Accumulation in Tomato and Defense against a Fungal Vascular Pathogen, Plant Physiology, 128, 150-159.
  76. Sessa, R.A, Bennett, M.H., Lewis ,M.J., Mansfield, J. W and Beale M.H (2000) Metabolite profiling of sesquiterpene lactones from Lactuca species. J. Biol. Chem. 275, 26877-26884.
  77. McLusky, S. R., Bennett, M.H., Beale, M.H., Lewis, M.J., Gaskin, P. and Mansfield, J. W. (1999) Cell-wall alterations and localised accumulation of feruloyl-3-methoxytyramine in onion epidermis at sites of attempted penetration by Botrytis alliii are associated with actin polarisation, peroxidase activity and suppression of flavonoid biosynthesis. Plant Journal, 17, 523-534.
  78. Cooper, R.M., Resende, M.L.V, Flood, J., Rowan M.G, Beale. M.H. and Potter, U., (1996) Detection and Cellular Location of Elemental Sulphur in Disease-resistant Genotypes of Threobroma cacao., Nature, 379, 159-162
  79. Perez-Amador, M.A., Carbonell, J., Navarro, J.L., Moritz, T., Beale, M.H., Lewis, M.J. and Hedden, P. (1996) N4-Hexanoylspermidine, a New polyamine-related Compound that Accumulates during Ovary and Petal Senescence in Pea. Plant Physiol. 110, 1177-1186.
  80. Bennett, M., Gallagher, M., Fagg, J., Bestwick, C., Paul, T., Beale, M.H. and Mansfield , J., (1996) The hypersensitive reaction, membrane damage and accumulation of autofluorescent phenolics in lettuce cells challenged by Bremia lactucae. Plant Journal, 9, 851-865
  81. Resende, M.L.V, Flood, J. Ramsden, J.D. , Rowan M.G, Beale. M.H. and Cooper, R.M. (1996) Novel phytoalexins including elemental sulphur in the resistance of cocoa (Threobroma cacao L.) to verticillium wilt (Verticillium dahliae Kleb). Physiol Mol. Plant Pathol. 48, 347-359

METABOLOMICS FACILITY – EXEMPLAR PUBLICATIONS

  1. Beale,M.H., Shewry, P.R and Napier, J.A. (2003) Production of High-value Chemicals in Plants. In Long Ashton Research Station:- 100 years of science in support of agriculture. (Eds Anderson, H. M., Lenton, J. R. and Shewry, P.R.) University of Bristol , Long Ashton Research Station. pp284-290.
  2. Lewis, J., Baker, J. Beale, M.H. and Ward, J. L. (2004) Metabolite Profiling of GM Plants: The Importance of Robust Experimental Design and Execution. In Genomics for Biosafety in Plant Biotechnology (Eds Nap, J.P.H., Atanassov, A and Stiekema, W.J) IOS Press, Amsterdam pp47-57.
  3. Humphrey A. J. and Beale M. H. (2005) Terpenes. In Plant Secondary Metabolites. Occurrence, structure and role in diet and health (eds Alan Crozier, Mike Clifford and Hiroshi Ashihara) Blackwells, Oxford pp 47 -101
  4. Jane L. Ward and Michael H. Beale (2005) NMR Spectroscopy in Plant Metabolomics, In Plant Metabolomics, Biotechnology in Agriculture and Forestry series, vol 57 (eds K. Saito, R. Dixon and L. Willmitzer) Springer, Heidelberg. 2006
  5. Jane L. Ward and Michael H. Beale.Proceedings of 4th International Conference on Plant Metabolomics.Metabolomics Journal Vol.2 No 4 Dec 2006 p269-334
  6. Keon, J. P.R., Antoniw, J. F., Carzaniga, R., Deller, S.,Ward, J. L., Baker, J. M., Beale, M. H., Hammond-Kosack, K. E. & Rudd, J. J. (2006) Transcriptional adaptation of Mycosphaerellagraminicola to programmed cell death (PCD) of its susceptible wheat host. Abstracts 3rd COGEME Interest Group Meeting, Manchester, 7-8 November 2006
  7. Lowe, R., Allwood, J. W., Urban, M., Beale, M. H., Ward, J. L., & Hammond-Kosack, K. E. (2007) DON Mycotoxin biosynthesis by Fusarium species, a metabolomics perspective. Abstracts BSPP Presidential meeting 2007 Attack and Defence in Plant Disease, Bath 12-14 September 200
  8. Shewry, P. R. ; Wan, Y. ; Wheeler, T. ; Gooding, M. ; Poole, R. ; Edwards, K. J. ; Mills, E. N. C. ; Skeggs, P. ; Gezan, S. ; Welham, S. ; Shenton, C. ; Zhu, T. ; Phillips, A. ; Jones, H. D. ; Li, L. ; Ward, J. ; Freeman, J. ; Nemeth, C. ; Mitchell, R. A. C. (2008) Improving wheat for nutrition and processing. Options Mediterraneennes.Serie A, Seminaires Mediterraneens 81, 249-252.
  9. Michael H. Beale, Jane L. Ward and John M. Baker.Establishing Substantial Equivalence: Metabolomics. 2009. in Transgenic Wheat, Barley and Oats Production and Characterization Protocols; Methods in Molecular Biology. Vol 478, 289-303. 2009. Huw D. Jones and Peter R. Shewry (Eds). Humana Press
  10. P.R. SHEWRY, S. MILLAR and J.L. WARD..The use of metabolomic profiling to identify new quality determinants in wheat. (Gluten Workshop, 2009)
  11. Huw D Jones, Kurt Gebruers, Jane Ward & Peter R Shewry. HealthGrain: Increasing the health benefits of wheat. international wheat quality conference iv. Saskatoon, Saskatchewan, Canada. June 2009
  12. Li Li, Claudia Harflett, Michael H. Beale and Jane L. Ward.(2009) Phenolic acids in Analysis of Bioactive Components in Small Grain Cereals (Eds Peter R. Shewry and Jane L. Ward. Published by AACC International, Minnesota, USA), 41-52
  13. Zoltan Bedő, Mariann Rakszegi and Laszlo Láng, Kurt Gebruers, VienoPiironen, DomenicoLafiandra, Jane Ward, Andy Phillips and Peter R. Shewry (2009) Combining bioactive components with conventional targets in plant breeding programs - in Analysis of Bioactive Components in Small Grain Cereals (Eds Peter R. Shewry and Jane L. Ward. Published by AACC International, Minnesota, USA), 263-272
  14. Jane L. Ward and Peter R. Shewry (2009) Future prospects for the analysis for bioactive components in cereal grain. in HEALTHGRAIN methods: analysis of bioactive components in small grain cereals; Editor(s): Shewry P. R.; Ward J. L. 273-280
  15. Robert D. Hall, Ric C.H. de Vos and Jane L Ward: Plant metabolomics applications in the Brassicaceae: added value for science and industry. Proceedings. 5th ISHS International symposium of Brassicas and the 16th Crucifer Genetics workshop (2010), Acta Horticulturae. 867, 191-206
  16. P.R. Shewry. L. Saulnier, F. Fuillon, K.Gebruers, C. Courtin, J. Delcour, G. Toole, D. Boros, J. Salse, C. Ravel, E.N.C. Mills, J. L. Ward, G. Charmet.(2010)Improving the benefits of wheat as a source of dietary fibre. In: dietary fibre: New frontiers for food and health. (Eds. J.W. van der Kamp, J.M. Jones, B.V. Mccleary and D.L. Topping), Wageningen Academic Publishers.Pp 65-78.
  17. Michael H Beale and Michael R Sussman (2011) Metabolomics of Arabidopsis, In Annual Plant Reviews: The Biology of Plant Metabolomics, Ed R Hall, Wiley-Blackwell. pp157-180
  18. Aimee M. Galster, Jennie Lewis, Sonia J. Miller, Delia-Irina Corol, Michael H. Beale and Jane L. Ward.(2012) Tissue Preparation using Arabidopsis In Methods in Molecular Biology 860, Plant Metabolomics, Methods and protocols Eds Nigel Hardy and Robert Hall, Humana Press, 65-81.
  19. John M. Baker, Jane L. Ward and Michael H. Beale. (2012) Combined NMR and Flow Injection ESI-MS for Brassicaceae metabolomics, In Plant Metabolomics, Methods and protocols, Methods in Molecular Biology 860, Eds Nigel Hardy and Robert Hall, Humana Press, 177-191.
  20. Michael H. Beale and Jane L. Ward. (2013) Hemiterpenoids as New Players in the Carbon-Nitrogen Economy. 50 Years of Phytochemistry Research, Volume 43 of the series Recent Advances in Phytochemistry pp 1-20

METABOLOMICS FACILITY – EXEMPLAR PUBLICATIONS

  1. Perez-Fons, L., Wells, T., Corol, D-I., Ward, J.L., Gerrish, C., Beale, M.H., Seymour, G.B., Bramley, P.M. and Fraser, P.D. (2014) A genome-wide metabolomic resource for tomato fruit from Solanum pennellii Nature:Scientific Reports, 4 : 3859 | DOI: 10.1038/srep03859
  2. Beste, D.J.V., Noh, K., Niedenfuhr, S., Mendum, T.A., Hawkins, N.D., Ward, J.L., Beale, M.H., Wiechart, W., McFadden, J. (2013) Carbon fixation and a mixed diet for the intra cellular tuberculosis bacillus.13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis. Cell:Chemistry and Biology, 20, 1012–1021.
  3. Ward, J.L., Baker, J.M., Llewellyn, A.M., Hawkins, N.D., Beale, M.H. (2011) Metabolomic analysis of Arabidopsis reveals hemiterpenoid glycosides as products of a nitrate ion-regulated, carbon flux overflow. Proc. Nat. Acad. Sci. USA 108(26), 10762-10767
  4. Ward, J.L., Forcat, S., Beckmann, M., Bennett, M., Miller, S.J., Baker, J.M., Hawkins, N.D., Vermeer,C., Lu, C., Lin, W., Truman, W.M., Beale, M.H., Draper, J., Mansfield, J.W., Grant, M. (2010) The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato. The Plant Journal, 63(3), 443-457.
  5. Baker, J.M., Hawkins, N.D., Ward, J.L., Lovegrove, A., Napier, J.A., Shewry, P.R., Beale, M.H. (2006). A metabolomic study of substantial equivalence of field-grown GM wheat.Plant Biotechnology Journal, 4(4), 381-392.
  6. Ward, J. L., Harris, C., Lewis, J. and Beale, M. H. (2003) Assessment of 1H-NMR spectroscopy and multivariate analysis as a technique for metabolite fingerprinting of Arabidopsis thaliana. Phytochemistry, 62, 949-957.

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